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recQ [2018-12-07 16:50:36]
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recQ [2018-12-07 16:50:36]

ATP-dependent DNA helicase, acts together with [protein|BA755FA1CB1E0C006E9A23489A7C8997141AA498|RecJ]
locus
BSU19220
pI
5.92
mw
67.18 kDa
protein length
591 aa Sequence Blast
gene length
1773 bp Sequence Blast
function
control of DNA recombination, maintenance of genomic stability
product
ATP-dependent DNA helicase
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.6|DNA repair/ recombination/ based on similarity]

    • Gene

    Coordinates
    2,094,010 → 2,095,785

    The protein

    Catalyzed reaction/ biological activity

  • unwinds covalently closed ds DNA (in complex with [protein|8DE39680CA7663803A107066FBE9AFFCC77DB72A|SSB]) [pubmed|10360177]
  • [protein|search|RecQ ]controls [protein|7D5327BD1DD5FD5F90B2C849589923AA3D8B20EF|Topo III] (de)catenation activity [pubmed|11497238,10360177]

    • Paralogous protein(s)

  • [protein|4A4FCD876C3CA1D821792803CA2A0CB2E97D3F5E|RecS]

    • Structure

  • [PDB|4O3M] (Bloom's syndrome helicase, 35% identity) [pubmed|24816114]

    • Expression and Regulation

    Operons

    genes
    [gene|E85341621B3835F63F07C506E08B73A92E588B1F|bsrB]-[gene|E6EA8098E37A4A2F7370920AC1A500EE4319AAA2|recQ]-[gene|BEBA71A2EF56DAEAF80924856DA68124805BB158|yocH]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-B414 (yocI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1413 NBRP B. subtilis, Japan]
  • BKE19220 (Δ[gene|E6EA8098E37A4A2F7370920AC1A500EE4319AAA2|recQ]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE19220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAACGTGTAAACCTCGCT, downstream forward: _UP4_TAAAAAAACAGAAAAACAAT
  • BKK19220 (Δ[gene|E6EA8098E37A4A2F7370920AC1A500EE4319AAA2|recQ]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK19220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAACGTGTAAACCTCGCT, downstream forward: _UP4_TAAAAAAACAGAAAAACAAT

    • References

    Reviews

  • 11497238,22933559,15217989

    • Original publications

  • 25246477,24816114